The one thing I lamented about the Apple II Plus (vs. the original with Integer BASIC) was that to make room for autostart, they had to rip out the mini-assembler in the Monitor ROM. That was the closest thing I ever saw to an assembly-language REPL before this. At least they were able to keep the disassembler.
It's common in the C64 world to use freezer cartridges that allow you to interrupt normal operation and invoke a monitor program. These typically include rudimentary assemblers and disassemblers as well. Fun and useful for patching and reverse engineering!
I also wish I could select from the completion list with Tab without typing more of the instruction, fish-style. I.e., you press Tab to go through completion 1, completion 2, ..., completion N, completion 1 again with Enter to confirm your pick.
With that said, I love the idea.